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Because of these risks, concomitant prescribing with these sedative medicines should be reserved for patients for whom alternative treatment options are not possible. Risk from concomitant use of sedative medicines such as benzodiazepines or related drugsĬoncomitant use of morphine and sedative medicines such as benzodiazepines or related drugs may result in sedation, respiratory depression, coma and death. The dose therefore should be carefully titrated to provide optimal pain relief. cirrhosis as this condition is likely to affect elimination. renal failure, because such patients can show signs of overdose following conservative dosage regimens.Ĭaution should be exercised in the use of Morphine in patients with impaired liver function e.g. In patients with disturbed Renal FunctionĬaution should be exercised in the use of Morphine in patients with renal dysfunction i.e. Morphine clearance decreases and half-life increase in older patients. The dose of morphine should be reduced in elderly patients and titrated to provide optimal pain relief with minimal side effects.
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This formulation is not recommended for use in children under 12 years. Therefore the dose should be gradually reduced prior to discontinuation. Withdrawal (abstinence) syndrome may be precipitated if opioid administration is suddenly discontinued (See Section 4.4). Daily doses will not usually exceed 100 mg per day in adults and adolescents over 12 years, however, in cancer patients chronic administration of higher doses up to 4 g per day may occasionally be required. In general, the minimum effective dose should be administered.įor intravenous administration it is important to inject morphine slowly over a period of 4 to 5 minutes with the patient in the recumbent position.įor continuous intravenous infusion of morphine, appropriate starting doses are 1-2 mg per hour in adults and adolescents over 12 years. Individuals might require considerably higher doses for sufficient relief of pain.
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